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Because your profile will be on all your CVs, you normally just mention the particular job sector you are applying for jobs in (e.g. publishing). A covering letter is normally used to apply for a specific advertised vacancy and so will focus on a particular job (e.g. editorial assistant in a particular publishing company Sometimes you may send out a speculative covering letter with your CV and here the focus will be broad, just like in the profile, as you don't know which jobs might be available.